Article
Th0 to Th1 switch of CD4 T cell clones specific from the 16-kDa antigen of Mycobacterium tuberculosis after successful therapy: lack of involvement of epitope repertoire and HLA-DR.
Immunology letters - 15 May 2005
Caccamo Nadia, Meraviglia Serena, Dieli Francesco, Romano Amelia, Titone Lucina, Salerno Alfredo
Abstract excerpt
In this study, we have examined the influence of HLA-DR molecules and the structure of the epitope repertoire of the 16-kDa protein of Mycobacterium tuberculosis on the acquisition of the cytokine secretion pattern of CD4 T cell clones, obtained from tuberculous patients before and after anti-mycobacterial therapy. Our data indicate that TB patients have a predominant Th0 response against the 16-kDa protein and...
Topics
- Amino Acid Sequence
- Antigens, Bacterial
- Cell Differentiation
- Cell Line
- Clone Cells
- Epitopes, T-Lymphocyte
- HLA-DR Antigens
- Humans
- Molecular Sequence Data
- Mycobacterium tuberculosis
- Phenotype
- Th1 Cells
- Tuberculosis