Article
Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X.
JAMA - 27 Apr 2005
Lindor Noralane M, Rabe Kari, Petersen Gloria M, Haile Robert, Casey Graham, Baron John, Gallinger Steve, Bapat Bharati, Aronson Melyssa, Hopper John, Jass Jeremy, LeMarchand Loic, Grove John, Potter John, Newcomb Polly, Terdiman Jonathan P, Conrad Peggy, Moslein Gabriella, Goldberg Richard, Ziogas Argyrios, Anton-Culver Hoda, de Andrade Mariza, Siegmund Kim, Thibodeau Stephen N, Boardman Lisa A, Seminara Daniela
Abstract excerpt
CONTEXT: Approximately 60% of families that meet the Amsterdam-I criteria (AC-I) for hereditary nonpolyposis colorectal cancer (HNPCC) have a hereditary abnormality in a DNA mismatch repair (MMR) gene. Cancer incidence in AC-I families with MMR gene mutations is reported to be very high, but canc...
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