Article
Pyridoxine effect in type I primary hyperoxaluria is associated with the most common mutant allele.
Kidney international - 1 May 2005
Monico Carla G, Rossetti Sandro, Olson Julie B, Milliner Dawn S
Abstract excerpt
BACKGROUND: Pyridoxine (VB6) response in type I primary hyperoxaluria (PHI) is variable, with nearly equal numbers of patients showing partial to complete reductions in oxaluria, and resistance. Because high urine oxalate concentrations cause stones and renal injury, reduction in urine oxalate excretion is deemed favorable. Mechanisms of VB6 action on hepatic alanine:glyoxylate aminotransferase (AGT), the...
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