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Article

Implications of genotype and enzyme phenotype in pyridoxine response of patients with type I primary hyperoxaluria.

American journal of nephrology - 1 Jan 2000

Monico Carla G, Olson Julie B, Milliner Dawn S

Abstract excerpt

BACKGROUND: Marked hyperoxaluria due to liver-specific deficiency of alanine:glyoxylate aminotransferase activity (AGT) characterizes type I primary hyperoxaluria (PHI). Approximately half of PHI patients experience improvement in the degree of hyperoxaluria following pyridoxine (VB6) treatment. Recently, we showed an association between VB6 response and the commonest PHI mutation G170R, with patients possessing...

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Source

Identifiers

PMID: 15849466
DOI: 10.1159/000085411

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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