Article
The relative importance of cytokine gene polymorphisms in the development of early and late acute rejection and six-month renal allograft pathology.
Transplantation - 15 Apr 2005
Tinckam Kathryn, Rush David, Hutchinson Ian, Dembinski Iga, Pravica Vera, Jeffery John, Nickerson Peter
Abstract excerpt
BACKGROUND: Acute rejection episodes and 6-month protocol biopsy acute pathology are highly correlated with long-term outcomes in renal transplant recipients. Recurrent, vascular, and late rejections are particularly deleterious. METHODS: We determined the relative contribution of human leukocyte antigen matching, cytokine genotypes, delayed graft function (DGF), and baseline immunosuppression to the development...
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