Article
Application of genome-wide expression analysis to human health and disease.
Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2005
Cobb J Perren, Mindrinos Michael N, Miller-Graziano Carol, Calvano Steve E, Baker Henry V, Xiao Wenzhong, Laudanski Krzysztof, Brownstein Bernard H, Elson Constance M, Hayden Douglas L, Herndon David N, Lowry Stephen F, Maier Ronald V, Schoenfeld David A, Moldawer Lyle L, Davis Ronald W, Tompkins Ronald G, Baker Henry V, Bankey Paul, Billiar Timothy, Brownstein Bernard H, Calvano Steve E, Camp David, Chaudry Irshad, Cobb J Perren, Davis Ronald W, Elson Constance M, Freeman Bradley, Gamelli Richard, Gibran Nicole, Harbrecht Brian, Hayden Douglas L, Heagy Wyrta, Heimbach David, Herndon David N, Horton Jureta, Hunt John, Laudanski Krzysztof, Lederer James, Lowry Stephen F, Maier Ronald V, Mannick John, McKinley Bruce, Miller-Graziano Carol, Mindrinos Michael N, Minei Joseph, Moldawer Lyle L, Moore Ernest, Moore Frederick, Munford Robert, Nathens Avery, O'keefe Grant, Purdue Gary, Rahme Laurence, Remick Daniel, Sailors Matthew, Schoenfeld David A, Shapiro Michael, Silver Geoffrey, Smith Richard, Stephanopoulos Gregory, Stormo Gary, Tompkins Ronald G, Toner Mehmet, Warren Shaw, West Michael, Wolfe Steven, Xiao Wenzhong, Young Vernon
Abstract excerpt
The application of genome-wide expression analysis to a large-scale, multicentered program in critically ill patients poses a number of theoretical and technical challenges. We describe here an analytical and organizational approach to a systematic evaluation of the variance associated with genome-wide expression analysis specifically tailored to study human disease. We analyzed sources of variance in genome-wide...
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