Article
Prevalence of large-scale mitochondrial DNA deletions in an adult Finnish population.
Neurology - 22 Mar 2005
Remes A M, Majamaa-Voltti K, Kärppä M, Moilanen J S, Uimonen S, Helander H, Rusanen H, Salmela P I, Sorri M, Hassinen I E, Majamaa K
Abstract excerpt
BACKGROUND: Large-scale mitochondrial DNA (mtDNA) deletions are associated with clinical conditions such as Kearns-Sayre syndrome and chronic progressive external ophthalmoplegia in adults and Pearson syndrome in children. Reported case series have suggested that deletions are not uncommon in the population, but their prevalence has not been documented. METHODS: The authors ascertained patients with clinical...
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