Article
Effect of sequence variation in meningococcal PorA outer membrane protein on the effectiveness of a hexavalent PorA outer membrane vesicle vaccine in toddlers and school children.
Vaccine - 8 Apr 2005
Findlow Jamie, Lowe Ann, Deane Sarah, Balmer Paul, van den Dobbelsteen Germie, Dawson Maureen, Andrews Nick, Borrow Ray
Abstract excerpt
Though meningococcal conjugate vaccines are effective against serogroup C, there is currently no vaccine solution for serogroup B disease. PorA outer membrane protein (OMP) is a potential serogroup B vaccine candidate. A hexavalent PorA outer membrane vesicle (OMV) vaccine has been evaluated in phase I and II trials with promising results. However, considerable sequence variation occurs in the variable regions...
Topics
- Antibodies, Bacterial
- Antibody Specificity
- Base Sequence
- Blood Bactericidal Activity
- Child
- Child, Preschool
- Cross Reactions
- Humans
- Meningococcal Vaccines
- Netherlands
- Phenotype
- Porins
- Vaccines, Conjugate