Article
Apoptosis of tail muscle during amphibian metamorphosis involves a caspase 9-dependent mechanism.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2005
Rowe Isaline, Le Blay Karine, Du Pasquier David, Palmier Karima, Levi Giovanni, Demeneix Barbara, Coen Laurent
Abstract excerpt
The climax of amphibian metamorphosis is marked by thyroid hormone-dependent tadpole tail resorption, implicating apoptosis of multiple cell types, including epidermal cells, fibroblasts, nerve cells, and muscles. The molecular cascades leading to and coordinating the death of different cell types are not fully elucidated. It is known that the mitochondrial pathway, and in particular the Bax and XR11 genes,...
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