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Article

Chromosomal Instability in Amniocytes From Fetuses of Mothers Who Smoke

8 Mar 2005

Abstract excerpt

CONTEXT: Tobacco increases the risk of systemic diseases, and it has adverse effects on pregnancy. However, only indirect data have been published on a possible genotoxic effect on pregnancy in humans. OBJECTIVES: To determine whether maternal smoking has a genotoxic effect on amniotic cells, expressed as an increased chromosomal instability, and to analyze whether any chromosomal regions are especially affected...

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PMID: 15755944
DOI: 10.1001/jama.293.10.1212

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