Prediction of collagen stability from amino acid sequence.

doi:10.1074/jbc.M501657200

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Article

Prediction of collagen stability from amino acid sequence.

The Journal of biological chemistry - 13 May 2005

Persikov Anton V, Ramshaw John A M, Brodsky Barbara

Abstract excerpt

An algorithm was derived to relate the amino acid sequence of a collagen triple helix to its thermal stability. This calculation is based on the triple helical stabilization propensities of individual residues and their intermolecular and intramolecular interactions, as quantitated by melting temperature values of host-guest peptides. Experimental melting temperature values of a number of triple helical peptides...

Topics

Algorithms
Amino Acid Motifs
Amino Acids
Animals
Collagen
Collagen Type I
Collagen Type II
Dimerization
Humans
Hydroxyproline
Mutation
Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Protein Folding

Protein Structure, Secondary

Protein Structure, Tertiary

Proteomics

Static Electricity

Source

Open in PubMed

Identifiers

PMID: 15753081
DOI: 10.1074/jbc.M501657200

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