Article
Genetic linkage analysis supports the presence of two susceptibility loci for alcoholism and heavy drinking on chromosome 1p22.1-11.2 and 1q21.3-24.2.
BMC genetics - 1 Mar 2005
Guerrini Irene, Cook Christopher C H, Kest Wendy, Devitgh Audrey, McQuillin Andrew, Curtis David, Gurling Hugh M D
Abstract excerpt
BACKGROUND: In order to confirm a previous finding of linkage to alcoholism on chromosome 1 we have carried out a genetic linkage study. METHODS: DNA from eighteen families, densely affected by alcoholism, was used to genotype a set of polymorphic microsatellite markers at loci approximately 10 centimorgans apart spanning the short arm and part of the long arm of chromosome 1. Linkage analyses were performed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.