Article
SARS transmission pattern in Singapore reassessed by viral sequence variation analysis.
PLoS medicine - 1 Feb 2005
Liu Jianjun, Lim Siew Lan, Ruan Yijun, Ling Ai Ee, Ng Lisa F P, Drosten Christian, Liu Edison T, Stanton Lawrence W, Hibberd Martin L
Abstract excerpt
BACKGROUND: Epidemiological investigations of infectious disease are mainly dependent on indirect contact information and only occasionally assisted by characterization of pathogen sequence variation from clinical isolates. Direct sequence analysis of the pathogen, particularly at a population level, is generally thought to be too cumbersome, technically difficult, and expensive. We present here a novel...
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