Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGFalpha expression impairs Trastuzumab-induced HER2 downregulation.

Oncogene - 21 Apr 2005

Valabrega Giorgio, Montemurro Filippo, Sarotto Ivana, Petrelli Annalisa, Rubini Patrizia, Tacchetti Carlo, Aglietta Massimo, Comoglio Paolo Maria, Giordano Silvia

Abstract excerpt

The HER2 gene encodes a tyrosine kinase receptor overexpressed in 25-30% of human breast cancers. Clinical trials have shown the efficacy of the anti-HER2 monoclonal antibody Trastuzumab in metastatic breast cancer patients. Nevertheless, 70% of patients are unresponsive from start of treatment and nearly all become unresponsive during treatment. Possible mechanisms for these failures could depend on impairment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Humanized

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents

Share to Down-Regulation

Share to Genes, erbB-2

Share to Transforming Growth Factor alpha

Share to Trastuzumab

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 15735715
DOI: 10.1038/sj.onc.1208478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

TGFalpha expression impairs Trastuzumab-induced HER2 downregulation.PMID 15735715Read ↗

Epigenetic silencing of TGFBI confers resistance to trastuzumab in human breast cancerSemantic proximity Read ↗

Disabling of the erbB Pathway Followed by IFN-γ Modifies Phenotype and Enhances Genotoxic Eradication of Breast Tumors.Semantic proximity Read ↗

Epigenetic downregulation of HER2 during EMT leads to tumor resistance to HER2-targeted therapies in breast cancerSemantic proximity Read ↗

Defective transforming growth factor beta signaling pathway in head and neck squamous cell carcinoma as evidenced by the lack of expression of activated Smad2.Semantic proximity Read ↗

Responsiveness to transforming growth factor-beta (TGF-beta)-mediated growth inhibition is a function of membrane-bound TGF-beta type II receptor in human breast cancer cells.Semantic proximity Read ↗

Decreased expression of TGF-beta cell surface receptors during progression of human oral squamous cell carcinoma.Semantic proximity Read ↗

Mad Upregulation and Id2 Repression Accompany Transforming Growth Factor (TGF)-β-mediated Epithelial Cell Growth SuppressionSemantic proximity Read ↗

Reversal of Tamoxifen Resistance of Human Breast Carcinomas In Vivo by Neutralizing Antibodies to Transforming Growth Factor-Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.