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Article

Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression.

Clinical pharmacology and therapeutics - 1 Mar 2005

Pinto Amar G, Wang Ying-Hong, Chalasani Naga, Skaar Todd, Kolwankar Dhanashri, Gorski J Christopher, Liangpunsakul Suthat, Hamman Mitchell A, Arefayene Million, Hall Stephen D

Abstract excerpt

BACKGROUND: Clarithromycin increases both hepatic and intestinal availability of the selective cytochrome P450 (CYP) 3A probe midazolam. This study was designed to identify determinants of variability in the extent of intestinal wall CYP3A inhibition by clarithromycin, such as CYP3A5 genotype, and the mechanism of inhibition. METHODS: Ten healthy volunteers received 500 mg oral clarithromycin twice a day for 7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15735612
DOI: 10.1016/j.clpt.2004.10.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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