Article
Size heterogeneity in the 3' noncoding region of South American isolates of yellow fever virus.
Journal of virology - 1 Mar 2005
Bryant Juliet E, Vasconcelos Pedro F C, Rijnbrand Rene C A, Mutebi J P, Higgs Stephen, Barrett Alan D T
Abstract excerpt
The 3' noncoding region (3' NCR) of flaviviruses contains secondary and tertiary structures essential for virus replication. Previous studies of yellow fever virus (YFV) and dengue virus have found that modifications to the 3' NCR are sometimes associated with attenuation in vertebrate and/or mosquito hosts. The 3' NCRs of 117 isolates of South American YFV have been examined, and major deletions and/or...
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