A comprehensive study of genic variation in natural populations of Drosophila melanogaster. V. Structural-functional constraints on protein molecules and enzymes and the levels and patterns of variation among genes.

Abstract excerpt

Ever since isozyme-allozyme polymorphisms were detected there has been an incessant effort to relate the amount of observed protein variation to various aspects of molecular structure and function. Structural-functional constraints can limit the amount of overall genic variation, and the observed variation can be due to neutral mutation and random genetic drift, mutation-selection balance, or balancing selection....

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