A comprehensive study of genic variation in natural populations of Drosophila melanogaster. V. Structural-functional constraints on protein molecules and enzymes and the levels and patterns of variation among genes.

Abstract excerpt

Ever since isozyme-allozyme polymorphisms were detected there has been an incessant effort to relate the amount of observed protein variation to various aspects of molecular structure and function. Structural-functional constraints can limit the amount of overall genic variation, and the observed variation can be due to neutral mutation and random genetic drift, mutation-selection balance, or balancing selection....

Topics

• Animals
• Drosophila melanogaster
• Enzymes
• Genetic Variation
• Proteins
• Regression Analysis
• Structure-Activity Relationship