Article
A combination of structural and cis-regulatory factors drives biochemical differences in Drosophila melanogaster malic enzyme.
Biochemical genetics - 1 Dec 2012
Rzezniczak Teresa Z, Lum Thomas E, Harniman Robert, Merritt Thomas J S
Abstract excerpt
The evolutionary significance of molecular variation is still contentious, with much current interest focusing on the relative contribution of structural changes in proteins versus regulatory variation in gene expression. We present a population genetic and biochemical study of molecular variation at the malic enzyme locus (Men) in Drosophila melanogaster. Two amino acid polymorphisms appear to affect...
Topics
- Amino Acid Sequence
- Animals
- Chromosomes, Insect
- Drosophila melanogaster
- Enzyme Activation
- Enzyme Stability
- Evolution, Molecular
- Female
- Gene Expression Regulation, Enzymologic
- Genes, Insect