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Intracellular multiplication of Legionella pneumophila depends on host cell amino acid transporter SLC1A5

4 Feb 2005

Abstract excerpt

The infectious agent of Legionnaires' disease, Legionella (L) pneumophila, multiplies intracellularly in eukaryotic cells. This study has been performed to explore the nutrient requirements of L. pneumophila during intracellular replication. In human monocytes, bacterial replication rate was reduced by 76% in defined medium lacking L-cysteine, L-glutamine or L-serine. SLC1A5 (hATB(0,+)), a neutral amino acid...

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PMID: 15720558
DOI: 10.1111/j.1365-2958.2005.04490.x

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