Article
Effect of thyroxine on abnormal pancreatic proteomes of the hypothyroid rdw rat.
Proteomics - 1 Mar 2005
Satoh Mamoru, Haruta-Satoh Eri, Omori Akira, Oh-Ishi Masamichi, Kodera Yoshio, Furudate Sen-Ichi, Maeda Tadakazu
Abstract excerpt
A mutation in the thyroglobulin (Tg) gene is the primary cause of hereditary dwarfism and hypothyroidism in the rdw rat. Despite the Tg mutation that causes a Tg shortage, rdw rats survive. The present study examines the influences of this condition on the pancreatic proteome. Normal control (group 1; n = 19) and rdw rats that did not receive L-thyroxine (T4) (group 2; n = 27) were sacrificed from 4 to 56 weeks...
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