Article
Role of arginine 220 in the oxygen sensor FixL from Bradyrhizobium japonicum.
The Journal of biological chemistry - 15 Apr 2005
Balland Véronique, Bouzhir-Sima Latifa, Kiger Laurent, Marden Michael C, Vos Marten H, Liebl Ursula, Mattioli Tony A
Abstract excerpt
In the heme-based oxygen sensor protein FixL, conformational changes induced by oxygen binding to the heme sensor domain regulate the activity of a neighboring histidine kinase, eventually restricting expression of specific genes to hypoxic conditions. The conserved arginine 220 residue is suggested to play a key role in the signal transduction mechanism. To obtain detailed insights into the role of this residue,...
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