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Article

The uncoupling of oxygen sensing, phosphorylation signalling and transcriptional activation in oxygen sensor FixL and FixJ mutants.

Molecular microbiology - 1 Apr 2003

Saito Ken, Ito Eiichi, Hosono Kaito, Nakamura Kayako, Imai Kiyohiro, Iizuka Tetsutaro, Shiro Yoshitsugu, Nakamura Hiro

Abstract excerpt

The rhizobial FixL/FixJ system, a member of the superfamily of bacterial two-component signal transducing systems, regulates the expression of nitrogen fixation-related genes by sensing environmental oxygen tension. Oxygen-free (deoxy) FixL is autophosphorylated at an invariant histidine residue with ATP, and the phosphoryl group is transferred to FixJ, leading to an enhancement in transcriptional activity at low...

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Identifiers

PMID: 12675798
DOI: 10.1046/j.1365-2958.2003.03446.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The uncoupling of oxygen sensing, phosphorylation signalling and transcriptional activation in oxygen sensor FixL and FixJ mutants.PMID 12675798Read ↗

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FixL of Rhizobium meliloti enhances the transcriptional activity of a mutant FixJD54N protein by phosphorylation of an alternate residue.Semantic proximity Read ↗

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