Article
Routes of phosphoryl group transfer during signal transmission and signal decay in the dimeric sensor histidine kinase ArcB.
The Journal of biological chemistry - 24 Aug 2018
Teran-Melo Juan L, Peña-Sandoval Gabriela R, Silva-Jimenez Hortencia, Rodriguez Claudia, Alvarez Adrián F, Georgellis Dimitris
Abstract excerpt
The Arc (anoxic redox control) two-component system of Escherichia coli, comprising ArcA as the response regulator and ArcB as the sensor histidine kinase, modulates the expression of numerous genes in response to respiratory growth conditions. Under reducing growth conditions, ArcB autophosphorylates at the expense of ATP, and transphosphorylates ArcA via a His292 → Asp576 → His717 → Asp54 phosphorelay, whereas...
Topics
- Aspartic Acid
- Escherichia coli
- Escherichia coli Proteins
- Histidine
- Membrane Proteins
- Mutation
- Phosphorylation
- Protein Kinases
- Signal Transduction
