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Article

Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23.

Cancer research - 15 Jan 2005

Bachinski Linda L, Olufemi Shodimu-Emmanuel, Zhou Xiaojun, Wu Chih-Chieh, Yip Linwah, Shete Sanjay, Lozano Guillermina, Amos Christopher I, Strong Louise C, Krahe Ralf

Abstract excerpt

Li-Fraumeni syndrome (LFS) is a clinically and genetically heterogeneous inherited cancer syndrome. Most cases ( approximately 70%) identified and characterized to date are associated with dominantly inherited germ line mutations in the tumor suppressor gene TP53 (p53) in chromosome 17p13.1. In a subset of non-p53 patients with LFS, CHEK2 in chromosome 22q11 has been identified as another predisposing locus....

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Source

Identifiers

PMID: 15695383

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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