Article
Genetic rescue of a Toxoplasma gondii conditional cell cycle mutant.
Molecular microbiology - 1 Feb 2005
White Michael W, Jerome Maria E, Vaishnava Shipra, Guerini Michael, Behnke Michael, Striepen Boris
Abstract excerpt
Growth rate is a major pathogenesis factor in the parasite Toxoplasma gondii; however, how cell division is controlled in this protozoan is poorly understood. Herein, we show that centrosomal duplication is an indicator of S phase entry while centrosome migration marks mitotic entry. Using the pattern of centrosomal replication, we confirmed that mutant ts11C9 undergoes a bimodal cell cycle arrest that is...
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