Article
Prognostic significance of Jab1 expression in laryngeal squamous cell carcinomas.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2005
Dong Youyi, Sui Li, Watanabe Yasuo, Yamaguchi Fuminori, Hatano Naoya, Tokuda Masaaki
Abstract excerpt
PURPOSE: Jun activation domain-binding protein 1 (Jab1) is known as a coactivator of AP1 transcription factor, which contributes to tumor progression by degrading the p27kip1 protein. The purpose of this study is to investigate whether Jab1 expression is correlated with p27kip1 level and cell proliferation, as well as whether Jab1 expression is associated with clinicopathologic variables and prognosis of...
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