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Article

Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma.

Cell death & disease - 1 Sept 2016

Zhang Jisheng, An Xiaofei, Han Yafei, Ma Rui, Yang Kun, Zhang Lu, Chi Jingwei, Li Wei, Llobet-Navas David, Xu Yan, Jiang Yan

Abstract excerpt

Histone H3 (H3K4) demethylase JARID1B is aberrantly upregulated in many types of tumor and has been proposed to function as oncogene. Here we show that JARID1B is elevated in moderate and high-differentiated human hypopharyngeal squamous cell carcinoma (HPSCC) compared with low-differentiated HPSCC. Overexpression of JARID1B in FaDu cells increased epithelial differentiation marker K10 expression and inhibited...

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Identifiers

PMID: 27584795
DOI: 10.1038/cddis.2016.262
PMCID: PMC5059865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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