Article
The familial Mediterranean fever (MEVF) gene as a modifier of Crohn's disease.
The American journal of gastroenterology - 1 Feb 2005
Fidder Herma, Chowers Yehuda, Ackerman Zvi, Pollak Rivka Dresner, Crusius J Bart A, Livneh Avi, Bar-Meir Simon, Avidan Benjamin, Shinhar Yael
Abstract excerpt
OBJECTIVES: Crohn's disease (CD) has been reported to be more frequent among non-Ashkenazi Jewish patients suffering from familial Mediterranean fever (FMF). Interestingly, functional similarities between the CD susceptibility gene (NOD2/CARD15) and the FMF gene (MEFV) have been described: both belong to the death domain containing protein family, important in the regulation of apoptosis, cytokine processing and...
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