Pathogenic hantaviruses bind plexin–semaphorin–integrin domains present at the apex of inactive, bent αvβ3 integrin conformers

Abstract excerpt

The alphavbeta3 integrins are linked to human bleeding disorders, and pathogenic hantaviruses regulate the function of alphavbeta3 integrins and cause acute vascular diseases. alphavbeta3 integrins are present in either extended (active) or dramatically bent (inactive) structures, and interconversion of alphavbeta3 conformers dynamically regulates integrin functions. Here, we show that hantaviruses bind human...

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