Article
Differential effects of clusterin/apolipoprotein J on cellular growth and survival.
Free radical biology & medicine - 15 Feb 2005
Trougakos Ioannis P, Lourda Magda, Agiostratidou Georgia, Kletsas Dimitris, Gonos Efstathios S
Abstract excerpt
The secreted clusterin/apolipoprotein J (CLU) protein form is a ubiquitously expressed heterodimeric glycoprotein which is differentially regulated in many severe physiological disturbance states including cell death, ageing, cancer progression, and various neurological diseases. Despite extensive efforts CLU function remains an enigma, the main cause being the intriguingly distinct and usually opposed functions...
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