Article
A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations.
Genes, chromosomes & cancer - 1 Apr 2005
Meyer Stefan, Fergusson William D, Oostra Anneke B, Medhurst Annette L, Waisfisz Quinten, de Winter Johan P, Chen Fei, Carr Trevor F, Clayton-Smith Jill, Clancy Tara, Green Mike, Barber Lisa, Eden Osborn B, Will Andrew M, Joenje Hans, Taylor G Malcolm
Abstract excerpt
Fanconi anemia (FA) is a rare autosomal recessive disorder characterized by congenital and developmental abnormalities, hypersensitivity to DNA cross-linking agents such as mitomycin C (MMC), and strong predisposition to acute myeloid leukemia (AML). In this article, we describe clinical and molecular findings in a boy with a severe FA phenotype who developed AML by the age of 2. Although he lacked a strong...
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