Article
Predictors of sensitivity and resistance to epidermal growth factor receptor inhibitors.
Clinical lung cancer - 1 Dec 2004
Perea Sofia, Hidalgo Manuel
Abstract excerpt
Lung cancer is one of the leading types of cancer with an associated high mortality. Currently, treatment with conventional cytotoxic agents remains suboptimal. Inhibition of the epidermal growth factor receptor (EGFR) with monoclonal antibodies or small-molecule inhibitors of the tyrosine kinase (TK) domain of the receptor have demonstrated modest, albeit significant, antitumor activities in patients with...
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