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Article

Recurrent deep vein thrombosis and pulmonary embolism in a young man with Klinefelter's syndrome and heterozygous mutation of MTHFR-677C>T and 1298A>C.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Jun 2010

Angel Joel R, Parker Stacey, Sells Ryan E, Atallah Ehab

Abstract excerpt

Klinefelter's syndrome is characterized by hypogonadism and infertility and commonly has an XXY karyotype. Within the population of men with this disorder, there is an increased incidence of venous thromboembolic disease. Although the precise mechanisms underlying this prothrombotic state have not been elucidated, it is thought that the increased incidence of thromboembolism is associated with a hypofibrinolytic...

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Source

Identifiers

PMID: 20449891
DOI: 10.1097/mbc.0b013e32833894eb

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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