Article
Application of a multiprobe RNase protection assay and junctional sequences to define V beta gene diversity in Sezary syndrome.
The American journal of pathology - 1 Apr 1992
Kono D H, Baccala R, Balderas R S, Kovac S J, Heald P W, Edelson R L, Theofilopoulos A N
Abstract excerpt
Nineteen patients with mycosis fungoides/Sezary syndrome (MF/SZ), a malignancy of the mature helper T-cell phenotype (CD4+TCR alpha beta+), were screened for clonotypic V beta expansions in peripheral blood with a multiprobe RNase protection assay. A different predominant V beta gene was identified in 9 of 14 patients with high peripheral blood CD4/CD8 ratios, whereas 4 of these patients showed T-cell expansions...
Topics
- Adult
- Aged
- Aged, 80 and over
- Base Sequence
- Cloning, Molecular
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Techniques
- Genetic Variation
- Humans
- Male