[Quantitative detection of serum hepatitis B wild type virus and the precore mutant genomes using competitive polymerase chain reaction in patients with HBeAg(-) chronic hepatitis B].

Abstract excerpt

We set up a competitive PCR assay to obtain simultaneously a quantitative estimation of HBV wild type (M0) and precore mutant (M1 M2) genomes in sera of patients with HBeAg negative chronic hepatitis B and their evolution during antiviral therapy. The results showed that the amount of HBV DNA declined to undetectable levels very rapidly after the beginning of therapy in responders, while in non responders, the...

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