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Article

Kinetic stability of Cu/Zn superoxide dismutase is dependent on its metal ligands: implications for ALS.

Biochemistry - 28 Dec 2004

Lynch Sandra M, Boswell Sarah A, Colón Wilfredo

Abstract excerpt

Over 100 mutants of the enzyme Cu/Zn superoxide dismutase (SOD) have been implicated in the neurodegenerative disease familial amyotrophic lateral sclerosis (FALS). Growing evidence suggests that the aggregation of SOD mutants may play a causative role in FALS and that aberrant copper chemistry, decreased thermodynamic stability, and decreased affinity for metals may contribute independently or synergistically to...

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Identifiers

PMID: 15610047
DOI: 10.1021/bi048831v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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