Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome.

doi:10.1002/eji.200425406

Article

Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome.

European journal of immunology - 1 Jan 2005

Harangi Mariann, Kaminski Wolfgang E, Fleck Martin, Orsó Evelyn, Zeher Margit, Kiss Emese, Szekanecz Zoltán, Zilahi Erika, Marienhagen Jörg, Aslanidis Charalampos, Paragh György, Bolstad Anne Isine, Jonsson Roland, Schmitz Gerd

Abstract excerpt

The genes for the human ATP-binding cassette (ABC) transporter ABCA7 and the minor histocompatibility antigen HA-1 are juxtaposed in close proximity on chromosome 19p13.3. The multispan transmembrane protein ABCA7 contains an extracellular domain that is recognized by antisera from patients with Sjögren's syndrome ("Sjögren-epitope"). Recent work from our laboratory demonstrating the involvement of ABCA7 in...

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Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome.

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