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Article

Binding and degradation of heterodimeric substrates by ClpAP and ClpXP.

The Journal of biological chemistry - 18 Feb 2005

Sharma Suveena, Hoskins Joel R, Wickner Sue

Abstract excerpt

ClpA and ClpX function both as molecular chaperones and as the regulatory components of ClpAP and ClpXP proteases, respectively. ClpA and ClpX bind substrate proteins through specific recognition signals, catalyze ATP-dependent protein unfolding of the substrate, and when in complexes with ClpP translocate the unfolded polypeptide into the cavity of the ClpP peptidase for degradation. To examine the mechanism of...

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Identifiers

PMID: 15591068
DOI: 10.1074/jbc.M412411200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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