Article
Insertional Polymorphisms of Endogenous HERV-K113 and HERV-K115 Retroviruses in Breast Cancer Patients and Age-Matched Controls
1 Nov 2004
Abstract excerpt
Endogenous retroviral sequences resulting from ancient retrovirus infections of germline cells account for up to 8% of the human genome. Most of these sequences are highly truncated, have been altered by mutations, and do not encode functional genes. However, some members of the human endogenous retrovirus (HERV)-K family are remarkably intact and display high genetic homology to mouse mammary tumor virus (MMTV),...
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