Article
Human blood genomics: distinct profiles for gender, age and neurofibromatosis type 1.
Brain research. Molecular brain research - 20 Dec 2004
Tang Yang, Lu Aigang, Ran Ruiqiong, Aronow Bruce J, Schorry Elizabeth K, Hopkin Robert J, Gilbert Donald L, Glauser Tracy A, Hershey Andrew D, Richtand Neil W, Privitera Michael, Dalvi Arif, Sahay Alok, Szaflarski Jerzy P, Ficker David M, Ratner Nancy, Sharp Frank R
Abstract excerpt
Application of gene expression profiling to human diseases will be limited by availability of tissue samples. It was postulated that germline genetic defects affect blood cells to produce unique expression patterns. This hypothesis was addressed by using a test neurological disease-neurofibromatosis type 1 (NF1), an autosomal dominant genetic disease caused by mutations of the NF1 gene at chromosome 17q11.2....
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