Dissecting the molecular mechanisms of human cancer: translating laboratory advances into clinical practice.

Abstract excerpt

There are multiple molecular mechanisms involved in human cancers with many genes involved, complex interactions and a variety of ways to examine them. Some events are already emerging as clinically important; others will turn out to be bystanders. By focussing on key genes, such as p53, the clinical implications of genetic changes and the pathways they link into are becoming apparent. Using the complex...

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