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Article

Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2004

Sammar Marei, Stricker Sigmar, Schwabe Georg C, Sieber Christina, Hartung Anke, Hanke Michael, Oishi Isao, Pohl Jens, Minami Yasuhiro, Sebald Walter, Mundlos Stefan, Knaus Petra

Abstract excerpt

The brachydactylies are a group of inherited disorders of the hands characterized by shortened digits. Mutations in the tyrosine kinase receptor Ror2 cause brachydactyly type B (BDB). Mutations in GDF5, a member of the BMP/TGF-beta ligand family, cause brachydactyly type C (BDC) whereas mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15569154
DOI: 10.1111/j.1365-2443.2004.00799.x

Genes

GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15569154-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of GDF5/BRI-b signalling through interaction with the tyrosine kinase receptor Ror2.PMID 15569154Read ↗

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome.Semantic proximity Read ↗

ROR-Family Receptor Tyrosine Kinases.Semantic proximity Read ↗

A new mutation in the gene ROR2 causes brachydactyly type B1.Semantic proximity Read ↗

A single residue of GDF-5 defines binding specificity to BMP receptor IB.Semantic proximity Read ↗

A novel R486Q mutation in BMPR1B resulting in either a brachydactyly type C/symphalangism-like phenotype or brachydactyly type A2.Semantic proximity Read ↗

Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B.Semantic proximity Read ↗

Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B.Semantic proximity Read ↗

The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.Semantic proximity Read ↗

Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2.Semantic proximity Read ↗

One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B.Semantic proximity Read ↗

Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development.Semantic proximity Read ↗

Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B.Semantic proximity Read ↗

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