Adeno-associated virus and the development of adeno-associated virus vectors: a historical perspective

Abstract excerpt

Adeno-associated virus (AAV) was discovered almost 40 years ago [1–3] and the first AAV vectors were described 20 years ago [4–6], which led to initiation of the first human clinical trial of an AAV vector some 8 years ago, in cystic fibrosis patients [7]. These events also delineate three periods in the history of AAV vector development. In the first 20 years, the basic elements of the AAV genome structure,...

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