Article
Effect of the 5' non-translated region on self-assembly of hepatitis C virus genotype 1a structural proteins produced in insect cells.
The Journal of general virology - 1 Dec 2004
Girard Christel, Ravallec Marc, Mariller Marcel, Bossy Jean-Pierre, Cahour Annie, López-Ferber Miguel, Devauchelle Gérard, Inchauspé Geneviève, Duonor-Cérutti Martine
Abstract excerpt
The effect of the 5' non-translated region (5'NTR) on hepatitis C virus (HCV) morphogenesis in insect cells is investigated in this study. Expression in baculovirus-infected cells of a sequence encoding the C and E1 structural proteins under the control of the very late promoter P10 (AcSLP10-C-E1) led to the synthesis of C and C-E1 complexes, essentially found in dense reticular material associated with the ER...
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