Article
Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function.
The Journal of biological chemistry - 28 Jan 2005
Pang Jian-Hong, Kraemer Astrid, Stehbens Samantha J, Frame Margaret C, Yap Alpha S
Abstract excerpt
Classical cadherin adhesion molecules can function as adhesion-activated cell-signaling receptors. One key target for cadherin signaling is the lipid kinase phosphoinositide (PI) 3-kinase, which is recruited to cell-cell contacts and activated by E-cadherin. In this study, we sought to identify upstream factors necessary for E-cadherin to activate PI 3-kinase signaling. We found that inhibition of tyrosine kinase...
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