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Evolutionary breakpoints are co-localized with fragile sites and intrachromosomal telomeric sequences in primates

12 Nov 2004

Abstract excerpt

The concentration of evolutionary breakpoints in primate karyotypes in some particular regions or chromosome bands suggests that these chromosome regions are more prone to breakage. This is the first extensive comparative study which investigates a possible relationship of two genetic markers (intrachromosomal telomeric sequences [TTAGGG]n, [ITSs] and fragile sites [FSs]), which are implicated in the evolutionary...

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PMID: 15545736
DOI: 10.1159/000080822

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