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Optimizing regulatable gene expression using adenoviral vectors

13 Nov 2004

Abstract excerpt

Inducible gene expression systems have typically encountered limitations, such as pleitropic effects of the inducer, basal leakiness, toxicity of inducing agents and low levels of expression. However, recently non-toxic, tightly regulated control of transgene expression has been reported for several systems, the most frequently cited being the tetracycline gene control system. We have found that the individual...

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PMID: 15542617
DOI: 10.1113/expphysiol.2004.028209

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