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Article

Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes.

Toxicology and applied pharmacology - 1 Dec 2004

Drobná Zuzana, Waters Stephen B, Walton Felecia S, LeCluyse Edward L, Thomas David J, Stýblo Miroslav

Abstract excerpt

Liver is a prime site for conversion of inorganic arsenic (iAs) to methylated metabolites, including methylarsenicals (MAs) and dimethylarsenicals (DMAs). To assess interindividual variation in the capacity of liver to metabolize iAs, we examined the metabolic fate of arsenite (iAs(III)) in normal primary human hepatocytes obtained from eight donors and cultured under standard conditions. Methylation rates,...

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Identifiers

PMID: 15541756
DOI: 10.1016/j.taap.2004.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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