Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physiological growth synergizes with pathological genes in experimental cardiomyopathy.

Circulation research - 10 Dec 2004

Syed Faisal, Odley Amy, Hahn Harvey S, Brunskill Eric W, Lynch Roy A, Marreez Yehia, Sanbe Atsushi, Robbins Jeffrey, Dorn Gerald W

Abstract excerpt

Hundreds of signaling molecules have been assigned critical roles in the pathogenesis of myocardial hypertrophy and heart failure based on cardiac phenotypes from alpha-myosin heavy chain-directed overexpression mice. Because permanent ventricular transgene expression in this system begins during a period of rapid physiological neonatal growth, resulting phenotypes are the combined consequences of transgene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Dilated
Share to Doxycycline

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits, Gq-G11

Share to Hypertrophy, Left Ventricular

Share to Mitochondria, Heart

Share to Myocardial Contraction

Share to Myocytes, Cardiac

Source

Identifiers

PMID: 15539635
DOI: 10.1161/01.RES.0000150366.08972.7f

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physiological growth synergizes with pathological genes in experimental cardiomyopathy.PMID 15539635Read ↗

Genetic Dissection of Cardiac Growth Control PathwaysSemantic proximity Read ↗

Various hypertrophic stimuli induce distinct phenotypes in cardiomyocytes.Semantic proximity Read ↗

Autonomous and growth factor-induced hypertrophy in cultured neonatal mouse cardiac myocytes. Comparison with rat.Semantic proximity Read ↗

Divergent transcriptional responses to independent genetic causes of cardiac hypertrophySemantic proximity Read ↗

Myocardial cell death and regeneration during progression of cardiac hypertrophy to heart failure.Semantic proximity Read ↗

Myocardin Induces Cardiomyocyte HypertrophySemantic proximity Read ↗

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic responseSemantic proximity Read ↗

Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growthSemantic proximity Read ↗

S100beta inhibits alpha1-adrenergic induction of the hypertrophic phenotype in cardiac myocytes.Semantic proximity Read ↗

Transcriptional regulation in cardiac muscle. Coordinate expression of Id with a neonatal phenotype during development and following a hypertrophic stimulus in adult rat ventricular myocytes in vitro.Semantic proximity Read ↗

EARLY ORIGINS OF CARDIAC HYPERTROPHY: DOES CARDIOMYOCYTE ATTRITION PROGRAMME FOR PATHOLOGICAL ‘CATCH‐UP’ GROWTH OF THE HEART?Semantic proximity Read ↗

Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.