Article
Physiological growth synergizes with pathological genes in experimental cardiomyopathy.
Circulation research - 10 Dec 2004
Syed Faisal, Odley Amy, Hahn Harvey S, Brunskill Eric W, Lynch Roy A, Marreez Yehia, Sanbe Atsushi, Robbins Jeffrey, Dorn Gerald W
Abstract excerpt
Hundreds of signaling molecules have been assigned critical roles in the pathogenesis of myocardial hypertrophy and heart failure based on cardiac phenotypes from alpha-myosin heavy chain-directed overexpression mice. Because permanent ventricular transgene expression in this system begins during a period of rapid physiological neonatal growth, resulting phenotypes are the combined consequences of transgene...
Topics
- Amino Acid Sequence
- Animals
- Animals, Newborn
- Aortic Coarctation
- Apoptosis
- Cardiomyopathy, Dilated
- Crosses, Genetic
- Doxycycline
- GTP-Binding Protein alpha Subunits, Gq-G11
- Gene Expression Regulation
- Genotype
- Heart
- Hypertrophy, Left Ventricular