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Article

Human Umbilical Cord Blood Cells Differentiate into Muscle in <i>sjl</i> Muscular Dystrophy Mice

1 Nov 2004

Abstract excerpt

Limb girdle muscular dystrophy type 2B form (LGMD-2B) and Miyoshi myopathy (MM) are both caused by mutations in the dysferlin (dysf) gene. In this study, we used dysferlin-deficient sjl mice as a mouse model to study cell therapy for LGMD-2B and MM. A single-blind study evaluated the therapeutic potential of human umbilical cord blood (HUCB) as a source of myogenic progenitor stem cells. Three groups of donor...

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PMID: 15536189
DOI: 10.1634/stemcells.22-6-981

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